A Clinical Trial to Investigate the Effect of Cynatine HNS on Hair and Nail Parameters
The Scientific World Journal
Christina Beer, Simon Wood and Robert H. Veghte
CB Food Consulting LLC, 320 Sherman Avenue, Salt Lake City, UT 84115, USA 2 Food, Nutrition and Health Program, Faculty of Land and Food Systems, University of British Columbia, 2357 Main Mall, Vancouver, BC, Canada V6T 1Z4 3 School of Public Health, Faculty of Health Sciences, Curtin University, Kent Street, Bentley, WA 6102, Australia 4 Roxlor Global LLC, 1013 Centre Road, Suite 106, Wilmington, DE 19805,
A new, novel product, Cynatine HNS, was evaluated for its effects as a supplement for improving various aspects of hair and nails in a randomized, double-blind, placebo-controlled clinical trial. Methods. A total of 50 females were included and randomized into two groups.Theactive group (𝑛 = 25) received 2 capsules containing Cynatine HNS, comprised of Cynatine brand keratin (500mg) plus vitamins and minerals, per day, and the placebo group (𝑛 = 25) received 2 identical capsules of maltodextrin per day for 90 days. End points for hair loss, hair growth, hair strength, amino acid composition, and hair luster were measured. End points were also measured for nail strength and the appearance of nails.
Cynatine HNS contains a protein called keratin, in a peptide form obtained by proprietary processing of New Zealand sheep wool. This novel ingredient is stable over a wide range of pH and under conditions of elevated temperature. Keratin protein is one of nature’s richest sources of cysteine. Based on this, we hypothesized that Cynatine HNS may act synergistically with the cells’ own antioxidant defense, boosting glutathione and other sulfur rich proteins and peptides. Keratin is the protein from which the majority of hair and nails are made. In vitro studies have shown that Cynatine HNS is highly bioavailable making it capable of delivering keratin peptides to the body, particularly to the hair and nails. Based on this, a randomized, doubleblind, placebo-controlled study was conducted to examine the ability of Cynatine HNS to improve end points for hair loss, hair growth, hair strength, amino acid composition, and the appearance of hair on the head aswell as the strength and appearance of nails.
The investigational product Cynatine HNS and placebo, provided by Roxlor Global, LLC, were given to the subjects as capsules packaged in blister packages. All Cynatine HNS capsules contained 250mg Cynatine (keratin), 7.5mg zinc, 9.0mg vitamin B3, 0.825mg copper, 6.84mg vitamin B5, 1.0mg vitamin B6, and 0.150mg vitamin B8 (Biotin) on an active dose basis. Each placebo capsule, identical in size, shape, and color, contained the inactive ingredients maltodextrin 370mg and magnesium stearate 5.0mg. On Day 1, subjects were instructed to take two capsules daily in the morning after breakfast.
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The results show that subjects taking Cynatine HNS showed statistically significant improvements in their hair and nails when compared to placebo. Conclusion. Cynatine HNS is an effective supplement for improving hair and nails in 90 days or less. EudraCT number is 2014-002645-22.